The Hypoxia Inducible Factor (HIF) is a transcription factor, which consists of an a and a β subunit. One of three α subunits dimerizes with one of two β...
Author - Davidl
The SCLC2A1 gene, which encodes a type 1 glucose transporter (GLUT1), responds to both HIF1α and HIF2α. Thus, both factors increase the cellular uptake of...
The general principles of signal transduction can by compared to air traffic between different countries, where countries symbolize the cells and airplanes carrying...
In the context of cancer therapy, antibodies produced outside the patient are used which are directed against secreted factors, membrane receptors or surface antigens of...
Onkoview 2010
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumour progression
By degradation of cell adhesion molecules, metalloproteases increase the motility of epithelial cells. Growth factors, which are bound to the plasma membrane, are...
Epithelial cells are in contact with the extracellular matrix. This video shows the acinus of a mammary gland surrounded by connective tissue. Fibroblasts, macrophages...
This video shows the formation of a metastatic thrombus. Tissue Factor (TF) in the cell membrane of the tumor cells activates factor VII, which in turn activates factor...
This video describes the bone loss through metastases of breast cancer. The CXCL12 chemokine formed by stromal cells of the bone marrow binds to the CXCR4 receptor of...
