The general principles of signal transduction can by compared to air traffic between different countries, where countries symbolize the cells and...
Category - Onkoview 2015
The most important family of receptor tyrosine kinases is the family of the receptors for EGF (Epidermal Growth Factor). Activation of the EGF...
Onkoview 2015
The EGF receptor tyrosine protein kinases and the therapy of tumors with activated EGF receptors – Part 1: Inhibition of receptor activation via antibodies
In many tumors, EGF receptors are over-activated, which leads to a stronger signal and a high rate of proliferation. In order to inhibit the signal...
Onkoview 2015
The EGF receptor tyrosine protein kinases and the therapy of tumors with activated EGF receptors – Part 2: Blocking of EGF receptor signaling via tyrosine kinase inhibitors
Tumors with activated EGF receptors can be treated with drugs that inhibit the kinase activity by binding to intracellular domains. Most of these...
The gene product of the BCR-ABL1 fusion gene is a kinase with a higher activity compared to the activity of the native ABL1 kinase. The analysis of...
More than 50 years ago, researchers detected typical chromosomal abnormalities in blood cells of patients with chronic myeloid leukemia (CML). These...
