Tumors are usually of clonal origin, that is, they arise from a single cell. The monoclonality of tumors can be seen, for example, in multiple myeloma, a tumor of the...
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The tumor suppressor protein p53 is a transcription factor. p53 monomers assemble into tetramers that bind to consensus sequences in the DNA and activate the...
The naturally occurring retinoic acid isomers 13-cis-retinoic acid and all-trans-retinoic acid (ATRA) influence processes of morphogenesis and differentiation. The...
The cell goes through typical stages between two cell divisions. The successive phases can be visualized as the so-called cell cycle. The cell cycle comprises two main...
The passage of a cell through the cell cycle is regulated by various proteins. Cyclin dependent kinases (CDKs) phosphorylate several substrates such as transcription...
The term apoptosis describes the regulated and gradual death of a cell. In contrast to uncontrolled necrosis, apoptosis is limited to one or a few cells and is not...
