The Hypoxia Inducible Factor (HIF) is a transcription factor, which consists of an a and a β subunit. One of three α subunits dimerizes with one of two β...
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The SCLC2A1 gene, which encodes a type 1 glucose transporter (GLUT1), responds to both HIF1α and HIF2α. Thus, both factors increase the cellular uptake of...
The general principles of signal transduction can by compared to air traffic between different countries, where countries symbolize the cells and airplanes carrying...
In the context of cancer therapy, antibodies produced outside the patient are used which are directed against secreted factors, membrane receptors or surface antigens of...
Onkoview 2010
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumour progression
By degradation of cell adhesion molecules, metalloproteases increase the motility of epithelial cells. Growth factors, which are bound to the plasma membrane, are...
Epithelial cells are in contact with the extracellular matrix. This video shows the acinus of a mammary gland surrounded by connective tissue. Fibroblasts, macrophages...
