Cells within growing tissues need a constant supply of oxygen. Under physiological conditions, the delivery of oxygen is well regulated; under...
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Onkoview 2015
Hypoxia Inducible Factors (HIFs), Part 2: Regulation of HIF under normoxic and hypoxic conditions
The Hypoxia Inducible Factor (HIF) is a transcription factor, which consists of an a and a β subunit. One of three α subunits dimerizes...
The SCLC2A1 gene, which encodes a type 1 glucose transporter (GLUT1), responds to both HIF1α and HIF2α. Thus, both factors increase the...
The general principles of signal transduction can by compared to air traffic between different countries, where countries symbolize the cells and...
In the context of cancer therapy, antibodies produced outside the patient are used which are directed against secreted factors, membrane receptors or...
Onkoview 2010
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumour progression
By degradation of cell adhesion molecules, metalloproteases increase the motility of epithelial cells. Growth factors, which are bound to the plasma...
