The hedgehog signaling pathway is constitutively active in cells of basal cell carcinoma and medulloblastoma. This activation is caused by the mutational inactivation or...
Playlist - The Hedgehog signaling pathway
Onkoview 2015
The hedgehog signaling pathway – Part 3: Inhibition of the Hedgehog pathway by drugs binding to Smoothened
Tumor cells with constitutively active hedgehog signaling pathway can be treated with drugs that bind directly to and inhibit Smoothened. Unfortunately, the effect of...
