Tumor cells with constitutively active hedgehog signaling pathway can be treated with drugs that bind directly to and inhibit Smoothened. Unfortunately, the effect of...
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The notch receptor consists of an extracellular domain that is non-covalently linked to a protein with a transmembrane and an intracellular domain. Notch signaling is...
NF-κB transcription factors can be activated by different pathways. The canonical NF-κB pathway starts with the activation of the TNFα receptor. The activated receptor...
The alternative NF-κB pathway is activated by several ligands such as CD40L or lymphotoxin β and their receptors. The activated receptor lifts the blockage of the...
The NF-kB pathway is constitutively active in multiple myeloma and other human tumors. The activation is based mainly on mechanisms that lead to an increased level...
Cells within growing tissues need a constant supply of oxygen. Under physiological conditions, the delivery of oxygen is well regulated; under pathological conditions...
