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Apoptosis

The term apoptosis describes the regulated and gradual death of a cell. In contrast to uncontrolled necrosis, apoptosis is limited to one or a few cells and is not accompanied by inflammation. Through apoptosis, the organism can get rid of cells, which are non-functional or which are...

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The EGF receptor tyrosine protein kinases

The most important family of receptor tyrosine kinases is the family of the receptors for EGF (Epidermal Growth Factor). Activation of the EGF receptor tyrosine kinase by extracellular EGF results in its dimerization and its autophosphorylation on its cytosolic domains. The phosphorylated...

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The EGF receptor tyrosine protein kinases and the therapy of tumors with activated EGF receptors – Part 2: Blocking of EGF receptor signaling via tyrosine kinase inhibitors

Tumors with activated EGF receptors can be treated with drugs that inhibit the kinase activity by binding to intracellular domains. Most of these drugs are ATP analogs that block ATP binding and thus prevent auto- and transphosphorylation by the intracellular receptor domains. Mutations...

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