NF-κB transcription factors can be activated by different pathways. The canonical NF-κB pathway starts with the activation of the TNFα receptor. The...
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The alternative NF-κB pathway is activated by several ligands such as CD40L or lymphotoxin β and their receptors. The activated receptor lifts the...
The NF-kB pathway is constitutively active in multiple myeloma and other human tumors. The activation is based mainly on mechanisms that lead to...
Cells within growing tissues need a constant supply of oxygen. Under physiological conditions, the delivery of oxygen is well regulated; under...
Onkoview 2015
Hypoxia Inducible Factors (HIFs), Part 2: Regulation of HIF under normoxic and hypoxic conditions
The Hypoxia Inducible Factor (HIF) is a transcription factor, which consists of an a and a β subunit. One of three α subunits dimerizes...
The SCLC2A1 gene, which encodes a type 1 glucose transporter (GLUT1), responds to both HIF1α and HIF2α. Thus, both factors increase the...