In the context of cancer therapy, antibodies produced outside the patient are used which are directed against secreted factors, membrane receptors or...
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The phosphatase PTEN dephosphorylates PIP3 to PIP2, which can then be hydrolyzed to DAG and IP3. In addition, PTEN performs many other functions by...
The naturally occurring retinoic acid isomers 13-cis-retinoic acid and all-trans-retinoic acid (ATRA) influence processes of morphogenesis and...
The phoshatidylinositol-3 kinase (PI3K) can be activated by binding directly or via the protein IRS-1 to the activated receptor tyrosine kinase...
Onkoview 2010
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumour progression
By degradation of cell adhesion molecules, metalloproteases increase the motility of epithelial cells. Growth factors, which are bound to the plasma...
Epithelial cells are in contact with the extracellular matrix. This video shows the acinus of a mammary gland surrounded by connective tissue...