In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein b-catenin leading to its degradation...
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The term apoptosis describes the regulated and gradual death of a cell. In contrast to uncontrolled necrosis, apoptosis is limited to one or a few...
The tumor suppressor protein p53 is a transcription factor. p53 monomers assemble into tetramers that bind to consensus sequences in the DNA and...
This video shows the formation of a metastatic thrombus. Tissue Factor (TF) in the cell membrane of the tumor cells activates factor VII, which in...
This video describes the bone loss through metastases of breast cancer. The CXCL12 chemokine formed by stromal cells of the bone marrow binds to the...
The MAPK pathway is dysregulated in more than 50 % of all human tumors. The pathway starts with the activation of a receptor tyrosine kinase, which...