Cells within growing tissues need a constant supply of oxygen. Under physiological conditions, the delivery of oxygen is well regulated; under pathological conditions...
Archive - Oktober 2021
Onkoview 2015
Hypoxia Inducible Factors (HIFs), Part 2: Regulation of HIF under normoxic and hypoxic conditions
The Hypoxia Inducible Factor (HIF) is a transcription factor, which consists of an a and a β subunit. One of three α subunits dimerizes with one of two β...
The SCLC2A1 gene, which encodes a type 1 glucose transporter (GLUT1), responds to both HIF1α and HIF2α. Thus, both factors increase the cellular uptake of...
In the context of cancer therapy, antibodies produced outside the patient are used which are directed against secreted factors, membrane receptors or surface antigens of...