The hedgehog signaling pathway is constitutively active in cells of basal cell carcinoma and medulloblastoma. This activation is caused by the...
Onkoview 2015
Layout C (with load more button)
Onkoview 2015
The hedgehog signaling pathway – Part 3: Inhibition of the Hedgehog pathway by drugs binding to Smoothened
Tumor cells with constitutively active hedgehog signaling pathway can be treated with drugs that bind directly to and inhibit Smoothened...
The notch receptor consists of an extracellular domain that is non-covalently linked to a protein with a transmembrane and an intracellular domain...
NF-κB transcription factors can be activated by different pathways. The canonical NF-κB pathway starts with the activation of the TNFα receptor. The...
The alternative NF-κB pathway is activated by several ligands such as CD40L or lymphotoxin β and their receptors. The activated receptor lifts the...
The NF-kB pathway is constitutively active in multiple myeloma and other human tumors. The activation is based mainly on mechanisms that lead to...
